Matrix Effects in Mass Spectrometry Analysis
نویسندگان
چکیده
منابع مشابه
An overview of matrix effects in liquid chromatography-mass spectrometry.
Matrix-dependent signal suppression or enhancement represents a major drawback in quantitative analysis with liquid chromatography coupled to atmospheric pressure ionization mass spectrometry (LC-API-MS). Because matrix effects (ME) might exert a detrimental impact on important method parameters (limit of detection, limit of quantification, linearity, accuracy, and precision), they have to be t...
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Matrix effects in mass spectrometry imaging (MSI) may affect the observed molecular distribution in chemical and biological systems. In this study, we use mouse brain tissue of a middle cerebral artery occlusion (MCAO) stroke model to examine matrix effects in nanospray desorption electrospray ionization MSI (nano-DESI MSI). This is achieved by normalizing the intensity of the sodium and potass...
متن کاملOvercoming matrix effects in liquid chromatography-mass spectrometry.
A major limitation in quantitative analysis with electrospray ionization mass spectrometry (ESI-MS) is represented by the so-called matrix effects in which the matrix coextracted with the analytes can alter the signal response, causing either suppression or enhancement, resulting in poor analytical accuracy, linearity, and reproducibility. In the direct electron ionization liquid chromatography...
متن کاملMethanol-associated matrix effects in electrospray ionization tandem mass spectrometry.
BACKGROUND Matrix effects can profoundly reduce the performance of electrospray ionization mass spectrometry. Preliminary observations indicated that the methanol used in the mobile phase could be a source of differential ionization or ion suppression. METHODS Drug stability studies, analysis of biological extracts, mixing experiments, and postcolumn infusions were used to test 9 commercial m...
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Matrix effects are dependent on biological fluid, ionization type, and sample preparation method. Although matrix effects are observed for both ionization types, ESI is especially susceptible, while APCI has proved to be less vulnerable. Sample preparation method has a clear influence on matrix effects as does, in particular, the choice of internal standard. When matrix effects result in severe...
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ژورنال
عنوان ژورنال: Analytical Sciences
سال: 2020
ISSN: 0910-6340,1348-2246
DOI: 10.2116/analsci.highlights2010